About Us

Advancing 3D cell culture in space with Expertise and Innovation

Advancing 3D cell culture in space with Expertise and Innovation

Welcome to the ESA ground based facility for BIOfabrication and ORganoid 3D culture Biosystems InTegration (Bio-Orbit), specialized in 3D cell culture to foster the advancement of space biology research. Thanks to the enduring expertise in microphysiological systems and biofabrication at Regenerative Medicine Technologies (RMT) Lab, we can help you to test your ideas for advanced biological experiments beyond Earth’s atmosphere.

At Bio-Orbit, our mission is clear: to propel the advancement of space biology fostering innovative research through cutting-edge technology and specific knowhow on 3D culture biosystems.

20

Expert Staff

6

Available technologies

Why Choose Us

Bio-Orbit aims to advance space biology to shape life beyond Earth, foster innovation, push exploration limits, and contribute to the scientific community.

High Quality Lab

Discover new opportunities in our state-of-the-art labs equipped with advanced technology for conducting precise and impactful space biology experiments.

Unmatched Expertise

Bio-Orbit, led by distinguished scientists and researchers, peovides a thorough expertise in 3D cell culture systems. Our leaders have a proven track record of impactful studies and are committed to driving the field forward.

Global Collaboration

Bio-Orbit offers unique chances for global collaboration with the ESA and other institutions. Join a network of researchers pushing scientific boundaries.

Qualified Staff

Bio-Orbit researchers have contributed to numerous studies, with successful projects and impactful research outcomes.

Bio-Orbit Expert Team

At Bio-Orbit, we take pride in our dedicated team of experts, who play a crucial role in shaping the future of space biology. Our team brings together a diverse range of skills and experiences, united by a passion for pushing the boundaries of scientific exploration.

Prof. Matteo Moretti

Head of Bio-Orbit

Eng. Giuseppe Talò

Senior Bioengineer

Dr. Chiara Arrigoni

Senior Scientist

Prof. Simone Bersini

Senior Scientist

Scientific publications of RMT Lab on microphysiological systems

  1. Petta D, D’Arrigo D, Salehi S, Talò G, Bonetti L, Vanoni M, Deabate L, De Nardo L, Dubini G, Candrian C, Moretti M, Lopa S, Arrigoni C. A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments. Materials Today Bio, 2024, 26,101072 IF 10,761
  2.  Lamouline A, Bersini S, Moretti M. In vitro models of breast cancer bone metastasis: analyzing drug resistance through the lens of the microenvironment, Frontiers in Oncology 13, (2023)
  3. Crippa M, Talò G, Lamouline A, Bolis S, Arrigoni C, Bersini S, Moretti M. A microfluidic model of human vascularized breast cancer metastasis to bone for the study of neutrophil-cancer cell interactions. Mater Today Bio. 2022 Oct 10;17:100460. IF 10,761
  4. Mainardi V.L., Sabato C., Rubert M., de Leeuw A., Arrigoni C., Dubini G., Candrian C., Moretti M, Müller R., Culture of 3D Bioprinted Bone Constructs Requires an Increased Fluid Dynamic Stimulation. Acta Biomaterialia 2022 Sep 13;S1742-7061(22)00573-6. IF 10,56
  5. Petta D, D’Amora U, D’Arrigo D, Tomasini M, Moretti M Musculoskeletal tissues-on-a-chip: role of natural polymers in reproducing tissue-specific microenvironments. Biofabrication 2022 Aug 31;14(4). IF 11,061
  6. Possenti L, Mecchi L, Rossoni A, Sangalli V, Bersini S, Cicchetti A, Costantino ML, Candrian C, Arrigoni C, Rancati T, Moretti M. Radiobiological Studies of Microvascular Damage through In Vitro Models: A Methodological Perspective. Cancers (Basel). 2021 Mar 9;13(5):1182 IF 6,64
  7. Colombo MV, Bersini S, Arrigoni C, Gilardi M, Sansoni V, Ragni E, Candiani G, Lombardi G, Moretti M. Engineering the early bone metastatic niche through human vascularized immuno bone minitissues. Biofabrication. 2021 Apr 26;13(3). IF 9,95
  8. Mainardi VL, Arrigoni C, Bianchi E, Talò G, Delcogliano M, Candrian C, Dubini G, Levi M, Moretti M. Improving cell seeding efficiency through modification of fiber geometry in 3D printed scaffolds. Biofabrication. 2021 Feb 12. IF 9,95
  9. Crippa M, Bersini S, Gilardi M, Arrigoni C, Gamba S, Falanga A, Candrian C, Dubini G, Vanoni M, Moretti M. A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation. Lab Chip. 2021 Mar 21;21(6):1061-1072 IF 6,8
  10. Mondadori C, Crippa M, Moretti M, Candrian C, Lopa S, Arrigoni C. Advanced Microfluidic Models of Cancer and Immune Cell Extravasation: A Systematic Review of the Literature. Front Bioeng Biotechnol. 2020 Aug 26;8:907 IF 5,89
  11. Petta D, Basoli V, Pellicciotta D, Tognato R, Barcik JP, Arrigoni C, Della Bella E, Armiento AR, Candrian C, Richards GR, Alini M, Moretti M, Eglin D, Serra T. Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks. Biofabrication. 2020 Sep 25. IF 9,95
  12. Lopa S, Piraino F, Talò G, Mainardi VL, Bersini S, Pierro M, Zagra L, Rasponi M, Moretti M. Microfluidic Biofabrication of 3D Multicellular Spheroids by Modulation of Non-geometrical Parameters. Front Bioeng Biotechnol. 2020 May 5;8:366. IF 5,89
  13. Marchetto A, Ohmura S, Orth MF, Knott MML, Colombo MV, Arrigoni C, Bardinet V, Saucier D, Wehweck FS, Li J, Stein S, Gerke JS, Baldauf MC, Musa J, Dallmayer M, Romero-Pérez L, Hölting TLB, Amatruda JF, Cossarizza A, Henssen AG, Kirchner T, Moretti M, Cidre-Aranaz F, Sannino G, Grünewald TGP. Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma. Nat Commun. 2020 May 15;11(1):2423. IF 14,919
  14. Arrigoni C, Lopa S, Candrian C, Moretti M. Organs-on-a-chip as model systems for multifactorial musculoskeletal diseases. Curr Opin Biotechnol. 2020 Jun;63:79-88. IF 9,74
  15. S. Bersini, Gilardi M, G.S. Ugolini, V. Sansoni, G Talò, S Perego, S Zanotti, P Ostano, M Mora, M Soncini, M Vanoni, G Lombardi, M Moretti. Engineering an environment for the study of fibrosis: A 3D human muscle model with endothelium-specificity and endomysium. Cell Rep. 2018 Dec 26;25(13):3858-3868 IF 8,032
  16. Bersini S, Miermont A, Pavesi A, Kamm RD, Thiery JP, Moretti M, Adriani G. A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells. Oncotarget. 2018 Nov 16;9(90):36110-36125. IF 5,168
  17. Lopa S, Mondadori C, Mainardi VL, Talò G, Costantini M, Candrian C, Święszkowski W, Moretti M. Translational Application of Microfluidics and Bioprinting for Stem Cell-Based Cartilage Repair. Stem Cells Int. 2018 Feb 20;2018:6594841. IF 3,989
  18. Bersini S, Gilardi M, Mora M, Krol S, Arrigoni C, Candrian C, Zanotti S, Moretti M. Tackling muscle fibrosis: From molecular mechanisms to next generation engineered models to predict drug delivery. Adv Drug Deliv Rev. 2018 Apr;129:64-77. IF 13,66
  19. Arrigoni C, Gilardi M, Bersini S, Candrian C, Moretti M. Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases. Stem Cell Rev. 2017 Jun;13(3):407-417. doi: 10.1007/s12015-017-9741-5. IF 3,612
  20. Zhang YS, Arneri A, Bersini S, […], Moretti M, […], Khademhosseini A. Bioprinting 3D Microfibrous Scaffolds for Engineering Endothelialized Myocardium and Heart-on-a-Chip. Biomaterials. 2016 Dec;110:45-59. IF 8,806
  21. Bersini S, Yazdi IK, Talò G, Shin SR, Moretti M, Khademhosseini A. Cell-microenvironment interactions and architectures in microvascular systems. Biotechnol Adv. 2016 Nov 1;34(6):1113-30. IF 11,452
  22. Bersini S, Arrigoni C, Lopa S, Bongio M, Martin I, Moretti M. Engineered miniaturized models of musculoskeletal diseases. Drug Discov Today. 2016 Apr 28. pii: S1359-6446(16)30120-9 IF 6,848
  23. Arrigoni C, Bongio M, Talò G, Bersini S, Enomoto J, Fukuda J, Moretti M. Rational Design of Prevascularized Large 3D Tissue Constructs using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels. Adv Healthc Mater. 2016 Jul;5(13):1617-26. IF 5,609
  24. Bongio M, Lopa S, Gilardi M, Bersini S, Moretti M. A 3D vascularized bone remodeling model combining osteoblasts and osteoclasts in a CaP nanoparticle-enriched matrix. Nanomedicine (Lond). 2016 May;11(9):1073-91 IF 5,005

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BIOS+ via Francesco Chiesa 5, 6500 Bellinzona, Switzerland

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+41 58 666 7105

Email Us

info@bio-orbit.eu

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